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一文梳理:BRAF V600E 突变型 CRC 靶向、免疫有何进展?化疗价值如何?
BRAF V600E 突变在结直肠癌(CRC)中是一个重要的生物标志物,约占所有结直肠癌病例的 10%。这一突变通常与肿瘤的侵袭性、预后不良以及对常规化疗的耐药性相关联[1]。研究显示,BRAF V600E 突变导致肿瘤细胞激活 MAPK ...
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