SARS-CoV-2 encodes a macrodomain (Mac1) within the nsp3 protein that removes ADP-ribose groups from proteins. However, its role during infection is not well understood. Evidence suggests that Mac1 ...
In this study, researchers targeted the macrodomain of SARS-CoV-2 called Mac1. This is thought to be the first high-throughput system that can screen for compounds that block macrodomain activity. In ...
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